You're eating precision fermentation foods already

From green queen

Precision fermentation has been around for decades, and most of us eat foods that contain ingredients made using the technology on a daily basis. Animal-free dairy makers are now using it to bring you the cheese and milk you love without the environmental cost.

As the alternative protein industry matures, it is increasingly under attack from food industry lobbies and interest groups. Of late, precision fermentation technology, used to create animal-free dairy foods, has been the target of the Non-GMO Project, a U.S. based non profit organization focused on alerting consumers to the presence of genetically modified organisms (GMO) in food products. In a press release published during National Dairy Month in the U.S., the organization described animal-free dairy made from precision fermentation as unregulated and dangerous. We thought it would be prudent to address the allegations as a matter of separating fact from fiction.

Let’s start with the most important facts: precision fermentation (PF) is a technology that has been around for 30 years, is entirely safe and is used in dozens (if not hundreds) of products you interact with every day. That cousin of yours that’s Type 1 diabetic? Her insulin is made using PF. The cheese you buy at the grocery store? The enzymes are made using PF. The vitamin supplement you give your teenager for their skin? PF again. That naturally flavored grapefruit soda you love? That’s right, it’s made using PF.

Here’s the thing. Until Perfect Day and its peers crash landed onto our food scene, most of us had never heard of precision fermentation. Now, this technology that we interact with regularly (though perhaps unknowingly), has been put under the microscope by everyone from chefs to media personalities to lobby groups. When something feels or sounds new, it’s entirely natural to have questions. Particularly when it’s related to the food we eat.

When it comes to animal-free dairy, precision fermentation refers to a process used to produce bio-identical milk proteins like casein or whey, without the use of animals. It is done by encoding milk protein DNA sequences into microorganisms, like yeast or fungi, and then fermenting them with nutrients and sugar in fermentation tanks, much like those used to brew beer. During the fermentation process, these unique microbes produce proteins, identical to those found in cow’s dairy milk. These proteins are filtered into a pure milk protein isolate that can be used to create our favorite dairy products such as cheese, yogurt and ice cream, without the use of animals.

The whole point of using precision fermentation is to produce the dairy products we love (think milk, cheese, yogurt) with a fraction of the carbon emissions, land requirements and water usage that the conventional dairy industry requires. This means the hundreds of millions of people who consume dairy products daily can do so without causing global warming.

 

FACT: Conventional dairy has a global warming problem

Let’s be clear, we are at a critical point in the climate change fight. Unless we significantly reduce the outsized climate impact from conventional agriculture, and that includes dairy farming, we will not be able to achieve the Paris Agreement goals. With half of all habitable land already being used for agriculture and 77% of that devoted to raising animals for food, anyone who is serious about creating a sustainable food industry knows that we cannot go on with the status quo. We certainly cannot nourish a growing global population with an agricultural system that already consumes too much land and water resources and drives biodiversity loss, while also emitting a third of global greenhouse gases. If global animal agriculture continues to expand, it will prevent the decarbonization of our agricultural system and perpetuate the increase of methane emissions, a greenhouse gas that is 86 times more powerful at warming the planet on a 20-year scale than carbon dioxide.

When it comes to conventional dairy production, it’s hard to argue with its environmental cost. Producing just one litre of milk releases 3.15kg of CO2, while one kilo of cheese releases a whopping 23.88kgs of CO2- about the same as burning 10kg of coal!

On the water front, things are not much better. To get one litre of milk requires 628 litres of water. A kilo of cheese demands an incredible 5,606 liters of water, the highest among all foods.

Beyond water and emissions, producing conventional dairy foods involves heavy use of antibiotics, a huge amount of arable land and GMO corn/soy animal feed, not to mention that the fields where these are grown are sprayed with pesticides and glyphosate.

FACT: You are already consuming precision fermentation foods and products

Precision fermentation is safely used to make insulin, most vitamins, flavors and countless enzymes found in nearly all commercially produced foods. We’ve all been eating foods produced with the aid of precision fermentation for decades. This is not new. Here’s an overview of common foods and supplements made using PF:

Enzymes: PF is used to make all sorts of enzymes used in food production, from amlysases to keep bread soft and prevent staleness, pectinases to make fruit juices clear instead of cloudy, transglutaminases to make deli meat products such as salami hold together better.

Vitamins: Almost all of the common vitamins we use to fortify foods (in powder form) or to supplement our own diets (in pill form) such as B vitamins (B2 and B12 in particular) and vitamins A, C, D, E and K, are made via precision fermentation technology.

Natural Flavors: Many flavorings and aromas regularly used in food are made via PF such as vanilla flavoring. When you see the term ‘natural flavors’ on an ingredient list? That’s PF too. The U.S. Food and Drug Administration (the FDA)’s own definition of “natural flavor/flavoring” includes ingredients made using precision fermentation.

Medicine: Specifically, insulin for Type 1 Diabetes patients to inject themselves with. Until the 1980s, we used to have to inject diabetes patients with insulin obtained from pigs and cows.

Cheese (this one is ironic, given the conventional dairy industry’s anti-PF stance): Rennet is a key ingredient in most cheeses. It is composed of the enzyme chymosin, which helps to separate the milk solids (the parts used in cheesemaking) from the liquids. In other words, rennet enables the formation of firm curds and is crucial in helping cheesemakers achieve their desired cheese texture. 80% of rennet used in global cheese produced comes from precision fermentation using microorganisms as host factories (the rest comes from the stomachs of ruminant animals). So chances are, if you have eaten dairy cheese, you have eaten PF-made rennet. 

FACT: Animal-free dairy is regulated by the US FDA

Animal-free dairy is a regulated industry. The U.S. FDA oversees and regulates any substance that is intentionally added to food as an additive through the GRAS Notification Program. This is also how enzymes, vitamins and flavors are regulated. To date, both Perfect Day and Remilk have followed this process prior to launching products in the U.S. market.

Animal-free dairy proteins do not fall under the USDA National Bioengineered Food Disclosure Standard, because the final product (animal-free milk protein) does not contain any detectable genetic material.

While genetic engineering techniques are used in creation of the microorganisms that produce the dairy proteins, they are filtered out at the end of fermentation. The resulting product is a high purity milk protein isolate, which is bio-identical to milk protein from cows. 

FACT: Animal-free dairy has a lower carbon and water footprint than conventional dairy

The planetary toll of the conventional industry when we are in the midst of a worsening climate crisis that is threatening our global food security is exactly why we need to rethink how we produce food and support nascent industries like animal-free dairy made from precision fermentation. This will allow consumers to continue enjoying the milk and cheese they crave and love at a lower cost to the planet.

In the RethinkX report on agriculture, the authors write that “modern alternatives will be up to 100 times more land efficient, 10-25 times more feedstock efficient, 20 times more time efficient, and 10 times more water efficient. They will also produce an order of magnitude less waste.”

According to a Life Cycle Assessment commissioned by Perfect Day, their technology allows for “a reduction in environmental impact of up to 99% less water use, up to 97% fewer greenhouse gas emissions, and up to 60% less renewable energy use compared to traditional (dairy) production methods.”

The future of our planet and the ability to feed next generations depends greatly on our ability to bring these new solutions to life. Precision fermentation is part of a broader ecosystem of sustainable food solutions, which include regenerative organic farming, plant-based foods and animal-free dairy. Without them we are at risk of losing the battle against climate change and in the years ahead, we will face unrelenting challenges to affordably feed 10 billion people.

CATL announces 1.5 million km battery

From The Driven

The world’s largest battery maker CATL has announced a new electric vehicle battery pack with a 1.5-million kilometre, 15-year warranty. For reference the average Australian passenger car drives less than 15,000 km per year so a 1.5 million km battery would last about 100 years worth of average driving.

The company has joined forces with Yutong Heavy Industries, who will be using the long life battery packs in their buses and heavy vehicles. Yutong, one of China’s largest bus manufacturers, began its first 10-year strategic partnership with CATL in 2012.

According to CnEVPost, CATL and Yutong signed a new 10-year strategic cooperation framework agreement in 2022.

The new lithium iron phosphate (LFP) battery will be able to cater to different market segments, including buses, light trucks and heavy trucks, and will be used in future products from Yutong Bus and Yutong Heavy Industries.

According to Don Imrie, who works in the electric bus industry and was interviewed by The Driven in 2023, the average metropolitan bus travels around 300 km per shift which means a 1.5 million km warranty would last around 13 years worth bus shifts driving every day of the year.

The long-life battery will also have zero degradation in the first 1,000 cycles, Yutong said. This effectively means a battery with 500 km of range would have zero capacity degradation for the first half million kilometres.

The new 1.5 million km warranty is the latest in series of breakthroughs coming from CATL. Last year the company announced it would begin mass production of a new “condensed” battery with 500 Wh/kg, almost double the energy density of the batteries currently used in Tesla vehicles.

The higher energy density batteries and longer lifecycles are the perfect solution for heavy vehicles such as buses and trucks which do a lot of kilometres and need to carry heavy payloads.

On top of the improved energy density and lifespan, CATL has also significantly reduced production costs over the past 12 months. In January the CATL announced it would reduce the cost per kWh of its lithium iron phosphate (LFP) cells by a stunning 50 per cent by mid 2024.

The rate at which CATL is reducing battery costs has surprised even technology analysts like Tony Seba, who 10 years ago predicted such low costs would only be reached in 2027.

It has been generally agreed for a decade, that when EV batteries fell to $100/kWh, the up-front cost disadvantage of EVs relative to ICEVs (petrol/diesel cars) would disappear.  Battery packs costing $50/kWh will mean that EVs will be not just cheaper to run (it's been that way for a while) but cheaper to buy too.  Which means in turn (a) that within the next 20 years, or less, emissions from land transport, currently ~20% of total emissions will end, and (b) that oil demand will plummet.

One final point:  Tony Seba was right.  Legacy auto executives didn't listen to him, and as a result are having to scurry to politicians to get protection from imported EVs, because they were too feckless and arrogant to move into EVs when it became obvious, a decade ago, that EVs were going to end up dominating the market.  He's made similar predictions about precision fermentation.  He's likely to be right here, too.   And that has massive implications for emissions and for farming.

Let's start with the cow

From a tweet thread by Tony Seba

Let me start with #insulin. In the 1970s, insulin was extracted from the pancreas of animals. In the 1980s, @Genentech, working with Eli Lilly (@LillyPad), developed insulin using a new technology that I call #PrecisionFermentation. It wasn’t animal insulin. It was human insulin.

The mainstream would say: “health care is slow, it can’t be disrupted.” Well, here’s the S-curve of #PrecisionFermentation human insulin. Human insulin disrupted animal insulin in about 13 years.









#PrecisionFermentation is a concept that I coined in my  @rethink_x report ‘Rethinking Food and Agriculture’ with @CatherineTubb in September 2019.

Think about beer #fermentation. You take a microorganism (a yeast) and feed it sugar, wheat, nitrogen.. and out comes beer.

The difference with #PrecisionFermentation: you genetically modify the yeast, so it can produce the ingredient you want. In this case, a #protein.

The #protein itself cannot be #GeneticallyModified. The yeast is, but there’s no genetic material in proteins. None. Anyone who tells you “#GMOprotein” is lying to you. Proteins have exactly no generic material.

How is #PrecisionFermentation going to disrupt #milk? — Milk is almost 90% water. 3.3% of milk is #proteins, and that is the commercially valuable part of #dairy. So, essentially, you disrupt 3% of that milk bottle and the entire dairy industry is gone.

The #PrecisionFermentation disruption of #dairy is a #B2B ingredient #disruption. No consumer behavior change is needed. All the industry needs to do is disrupt protein shakes, protein bars etc. and ⅓ of #dairy industry revenues go away.

This technology has existed for 40 years and they’ve gone through an incredible capability cost curve. #PrecisionFermentation dairy proteins are already in the market (cheese, chocolate, ice cream etc). This is not in the future. This is now.

To give you an idea of the cost curve of #PrecisionFermentation, between 2000 and 2020, the cost per kilo/pound went down by about 10,000x in 20 years from ~$1m to ~$100. That cost curve makes #MooresLaw (computing) look like a straight line into the future.




Over the next ten years, we’re going to experience the #disruption of #food and #agriculture. And I am going to focus on the cow.

Because the cow is — by far — the most inefficient food production technology on the planet.

Every #animal that we use for #livestock is going to be #disrupted. If the cost curve keeps improving the way it has over the last few decades, the cost-per-kilo of #PrecisionFermentation proteins will reach price parity with the cow by ~2025. That’s only three years away.

We know that in #food and #ingredients, #disruptions happen quickly and they happen as S-curves. Think about Pepsi and Coca Cola. In the 1980s, in the United States, they went from all cane sugar to all corn-based sugar in only four years.

This is not a “veggie revolution”.  What is happening today is the ‘Second Domestication of Plants and Animals’. We’re going from domesticating large organisms — cow sheep horse chicken — to microorganisms as a source of food.

#PrecisionFermentation proteins are 5-100x more resource-efficient than the cow. #PFproteins, casein and whey, can be made today using 100x less land than the cow. Think about it. 100x less land.

An Israeli company called @Remilk_Foods announced that they’re going to open the world’s largest facility to create cow-free milk in Denmark. They’re going to make the dairy equivalent of 50,000 cows on 750,000 sq-ft = a standard industrial-size facility. A fermentation farm.

Canada’s dairy industry has about 1 million cows (whole country). Take 20 @Remilk_Foods facilities, i.e. #PrecisionFermentation farms, and they could produce the equivalent of 1m cows. This would take 344 acres and disrupt the whole dairy industry in Canada. That’s it. Gone!

How quickly is this going to happen? — The CEO of @Remilk_Foods says they can produce dairy as cheap as animal protein by 2024, which is within the cost curve that I published 3 years ago. That’s only 3 years away, not 20 or 30 as the mainstream would suggest. We need to prepare.

#FermentationFarms are the new #FoodFarms where we are going to create our proteins. New business model innovations and possibilities will open up, in this case, for example: #FoodAsSoftware.

The #proteins we eat today come from just a few #plants and #animals that we domesticated thousands of years ago. 12 plants and 5 animals account for 75% of food. There are millions of plants & animals on Earth. There’s a huge possibility space out there. #PrecisionFermentation

With #FoodAsSoftware and #PrecisionFermentation, we can make proteins from any animal, from any plant, at speed and scale. The number of possible #proteins mathematically is infinite. I did the numbers. It is larger than the number of atoms in the universe.

And it’s not just about the cow. It’s not even about food. #PrecisionFermentation is disruptive across many sectors. It’s being used for #cosmetics. #Collagen, for instance. #HumanCollagen is being made with precision fermentation. Today!

#SweetProteins are going to be so disruptive! One of those proteins — #brazzein — is ~1000x sweeter than cane sugar. 1 pound of brazzein can sweeten the equivalent of 1000 pounds of sugar. Think about that! Without the #insulin reaction.

The magic #ingredient that makes  @ImpossibleFoods’ meat smell and taste like meat is #heme. Heme is only 2% of their burgers. Think about how  @generalelectric got disrupted with only 2% market penetration of solar, wind & batteries (#SWB). Same thing is happening with #meat.

And you may think: “will this fly in x” or “will they eat it in #Texas?” — Yes, they will. I was at the airport in #Houston, and sure enough, they’re selling #ImpossibleNachos & #ImpossibleQuesadillas. And the menu doesn’t even say it’s vegetarian.








This is not just the #disruption of the cow. This is the disruption of all food that comes from animals: pork, fish eggs etc. All of them can be, and will be, disrupted by #PrecisionFermentation and #FoodAsSoftware.

I expect three phases in the “#Disruption of #Food & #Agriculture”. What we’re undergoing now is the first phase, which is #ingredients, #B2B etc.

The second phase, which starts around 2024, is more complex proteins & meats that will be made with #PrecisionFermentation, and later, #CellularAgriculture.

I expect that the animal extraction industry, the livestock-as-food industry, will be gone by 2035. It’s pretty much over. I expect the dairy industry to be bankrupt by 2030 — that’s less than 10 years away — and the whole livestock industry by 2035.

That doesn’t mean you can’t eat a cow after 2035. You can, but it’s going to be a little bit like the horse and the car. You can still ride horses, but it’s not a mainstream form of transportation, and it’s very expensive. Eating cows will be just like owning a horse today


For those of you who think Tony Seba's views are way out there .... you're wrong. He has consistently called it right for at least a decade. He understands that new technologies grow *exponentially*, not linearly.  And given how high emissions from beef, mutton and other meats are, this could save the world.  Because if we're all eating vat meat and vat eggs and drinking vat milk, then all that land freed up by ending animal husbandry will be able to revert to forest.  And that will be the most powerful carbon capture and storage process we could have.

Precision fermentation

From a tweet thread by Joel Scott-Halkes

You might not know it, but you're already eating ingredients made with precision fermentation (PF). Whilst recent breakthroughs mean that PF can now make milk, ice cream and cheese, here's 5 of the very surprising PF things you're ALREADY eating ( You’re Already Eating Foods With Ingredients Made Using Precision Fermentation, So Why The Fuss About Animal-Free Dairy? )

Surprising PF ingredient #1: Vanilla flavouring. Most of the time you eat something vanilla flavoured you're actually eating PF 'vanillin', essentially the pure essence of vanilla flavour. Annual global sales of vanillin are more than 15m kg. More than 99% of it is PF!

Surprising PF ingredient #2: Rennet. Cheesemaking needs rennet to make milk curdle. Historically this came from the 4th stomach of a slaughtered calf . The active ingredient is an enzyme called chymosin & is easily made with PF. Today 80% of global cheese uses PF rennet!

Surprising PF ingredient #3: Insulin Until the 1980s if you wanted to get just 1kg of insulin, you had to kill 50,000 pigs and harvest their pancreases. Today, more 99% of insulin is derived from PF created by genetically engineered yeast.

Surprising PF ingredient #4: Amylase All sorts of PF enzymes are used in food today. One of the most important is amylase which helps make bread soft and delicious. Amylase helps turn starches into sugars to feed the yeast in the rising process. ( Amylase: The Fabio of the Bread World )

Last one: PF ingredient #5: Vitamins Ever eaten something fortified with vitamins? Most of those vitamins were likely created with precision fermentation - especially B vitamins (B2 and B12 in particular) and vitamins A, C, D, E and K. ( Microbial Cell Factories for Green Production of Vitamins )

Source: green queen

 

The green technology that could save us all

From The Guardian

So what do we do now? After 27 summits and no effective action, it seems that the real purpose was to keep us talking. If governments were serious about preventing climate breakdown, there would have been no Cops 2-27. The major issues would have been resolved at Cop1, as the ozone depletion crisis was at a single summit in Montreal.

Nothing can now be achieved without mass protest, whose aim, like that of protest movements before us, is to reach the critical mass that triggers a social tipping point. But, as every protester knows, this is only part of the challenge. We also need to translate our demands into action, which requires political, economic, cultural and technological change. All are necessary, none are sufficient. Only together can they amount to the change we need to see.

Let’s focus for a moment on technology. Specifically, what might be the most important environmental technology ever developed: precision fermentation.

Precision fermentation is a refined form of brewing, a means of multiplying microbes to create specific products. It has been used for many years to produce drugs and food additives. But now, in several labs and a few factories, scientists are developing what could be a new generation of staple foods.

The developments I find most interesting use no agricultural feedstocks. The microbes they breed feed on hydrogen or methanol – which can be made with renewable electricity – combined with water, carbon dioxide and a very small amount of fertiliser. They produce a flour that contains roughly 60% protein, a much higher concentration than any major crop can achieve (soy beans contain 37%, chick peas, 20%). When they are bred to produce specific proteins and fats, they can create much better replacements than plant products for meat, fish, milk and eggs. And they have the potential to do two astonishing things.

The first is to shrink to a remarkable degree the footprint of food production. One paper estimates that precision fermentation using methanol needs 1,700 times less land than the most efficient agricultural means of producing protein: soy grown in the US. This suggests it might use, respectively, 138,000 and 157,000 times less land than the least efficient means: beef and lamb production. Depending on the electricity source and recycling rates, it can also enable radical reductions in water use and greenhouse gas emissions. Because the process is contained, it avoids the spillover of waste and chemicals into the wider world caused by farming.

If livestock production is replaced by this technology, it creates what could be the last major opportunity to prevent Earth systems collapse, namely ecological restoration on a massive scale. By rewilding the vast tracts now occupied by livestock (by far the greatest of all human land uses) or by the crops used to feed them – as well as the seas being trawled or gill-netted to destruction – and restoring forests, wetlands, savannahs, natural grasslands, mangroves, reefs and sea floors, we could both stop the sixth great extinction and draw down much of the carbon we have released into the atmosphere.

The second astonishing possibility is breaking the extreme dependency of many nations on food shipped from distant places. Nations in the Middle East, north Africa, the Horn of Africa and Central America do not possess sufficient fertile land or water to grow enough food of their own. In other places, especially parts of sub-Saharan Africa, a combination of soil degradation, population growth and dietary change cancels out any gains in yield. But all the nations most vulnerable to food insecurity are rich in something else: sunlight. This is the feedstock required to sustain food production based on hydrogen and methanol.

Precision fermentation is at the top of its price curve, and has great potential for steep reductions. Farming multicellular organisms (plants and animals) is at the bottom of its price curve: it has pushed these creatures to their limits, and sometimes beyond. If production is distributed (which I believe is essential), every town could have an autonomous microbial brewery, making cheap protein-rich foods tailored to local markets. This technology could, in many nations, deliver food security more effectively than farming can.

There are four main objections. The first is “Yuck, bacteria!” Well, tough, you eat them with every meal. In fact, we deliberately introduce live ones into some of our foods, such as cheese and yoghurt. And take a look at the intensive animal factories that produce most of the meat and eggs we eat and the slaughterhouses that serve them, both of which the new technology could make redundant.

The second objection is that these flours could be used to make ultra-processed foods. Yes, like wheat flour, they could. But they can also be used to radically reduce the processing involved in making substitutes for animal products, especially if the microbes are gene-edited to produce specific proteins.

This brings us to the third objection. There are major problems with certain genetically modified crops such as Roundup Ready maize, whose main purpose was to enlarge the market for a proprietary herbicide, and the dominance of the company that produced it. But GM microbes have been used uncontroversially in precision fermentation since the 1970s to produce insulin, the rennet substitute chymosin and vitamins. There is a real and terrifying genetic contamination crisis in the food industry, but it arises from business as usual: the spread of antibiotic resistance genes from livestock slurry tanks, into the soil and thence into the food chain and the living world. GM microbes paradoxically offer our best hope of stopping genetic contamination.

The fourth objection has more weight: the potential for these new technologies to be captured by a few corporations. The risk is real and we should engage with it now, demanding a new food economy that’s radically different from the existing one, in which extreme consolidation has already taken place. But this is not an argument against the technology itself, any more than the dangerous concentration in the global grain trade (90% of it in the hands of four corporations) is an argument against trading grain, without which billions would starve.

The real sticking point, I believe, is neophobia. I know people who won’t own a microwave oven, as they believe it will damage their health (it doesn’t), but who do own a woodburning stove, which does. We defend the old and revile the new. Much of the time, it should be the other way around.

I’ve given my support to a new campaign, called Reboot Food, to make the case for the new technologies that could help pull us out of our disastrous spiral. We hope to ferment a revolution.

[George Monbiot is a Guardian columnist]

Source: Precision Fermentation: What exactly is it?